clinical advisory

Clinical Advisory from NINDS

The National Institute of Neurological Disorders and Stroke (NINDS) issued a new Clinical Advisory on September 19, 2011:

Secondary Prevention of Small Subcortical Strokes Trial: NINDS Stops Treatment with Combination Antiplatelet Therapy (Clopidogrel plus Aspirin) Due to Higher Risk of Major Hemorrhage and Death (http://www.nlm.nih.gov/databases/alerts/2011_ninds_stroke.html)

NINDS has stopped the combination antiplatelet intervention in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial. This was a randomized, multicenter clinical trial conducted throughout North America, Latin America and Spain, to learn about preventing a second stroke in patients who had a subcortical stroke and to learn how to prevent cognitive problems after a stroke.

However, the DSMB strongly recommended that the blood pressure intervention component of the trial be continued without modification. All participants are encouraged to continue taking aspirin and blood pressure control medications and to remain active in the trial, which is expected to complete follow-up by April 2012.

Further information about this trial (NCT00059306) can be found at http://www.clinicaltrials.gov.