May 23, 2023
Critical care physician Hollis O'Neal, MD, MSc, Associate Professor of Medicine at LSU Health New Orleans School of Medicine’s Baton Rouge campus, presented data that validate a rapid diagnostic test for sepsis at the American Thoracic Society 2023 International Conference. Dr. O’Neal is the national principal investigator of the CV-SQulSH-ED trial, a multi-site prospective study to evaluate the diagnostic performance of the investigational Cytovale System & IntelliSep Test for patients presenting to the Emergency Department with signs or suspicion of infection. The IntelliSep Test is a microfluidic test that measures the biophysical properties of white blood cells (leukocytes) in conjunction with other laboratory findings and clinical assessments to aid in the early detection of sepsis.
"Every minute counts when it comes to sepsis diagnosis, and EDs operate under major time and resource constraints that could impact patient outcomes,” said Dr. O’Neal, who also serves as Medical Director of Research at Our Lady of the Lake Regional Medical Center, LSU Health’s major teaching hospital in Baton Rouge. “These results validate the efficacy and efficiency of IntelliSep as a diagnostic aid that may improve sepsis triage when incorporated into existing clinical protocols."
According to the National Institutes of Health, sepsis is a person’s overwhelming or impaired whole-body immune response to an insult— bacterial infections, viral infections, such as COVID-19 or influenza; or fungal infections. It is unpredictable and can progress rapidly. Without prompt treatment, sepsis can lead to tissue damage, organ failure and death. It’s a serious condition and a leading cause of death in hospitals. It’s also a main reason why people are readmitted to the hospital. Each year, according to the Centers for Disease Control and Prevention (CDC), at least 1.7 million adults in the U.S. develop sepsis, and nearly 270,000 die as a result. The number of sepsis cases per year in the U.S. has been on the rise. Many patients who survive severe sepsis recover completely, but some people can have permanent organ damage.The researchers conclude that, if integrated into a process of clinical decision making, the ISI has the potential to improve the efficiency and efficacy of sepsis care delivery in the Emergency Department.
The research was funded by the Department of Health and Human Services; the Administration for Strategic Preparedness and Response; and Biomedical Advanced Research and Development Authority, under contract number 75A50119C00072.______________________________________________________________________________________________________________ LSU Health Sciences Center New Orleans (LSU Health New Orleans) educates Louisiana's health care professionals. The state's health sciences university leader, LSU Health New Orleans includes a School of Medicine with campuses in Baton Rouge and Lafayette, the state's only School of Dentistry, Louisiana's only public School of Public Health, and Schools of Allied Health Professions, Nursing, and Graduate Studies. LSU Health New Orleans faculty take care of patients in public and private hospitals and clinics throughout the region. In the vanguard of biosciences research, the LSU Health New Orleans research enterprise generates jobs and enormous annual economic impact. LSU Health New Orleans faculty have made lifesaving discoveries and continue to work to prevent, advance treatment or cure disease. To learn more, visit http://www.lsuhsc.edu, http://www.twitter.com/LSUHealthNO, or http://www.facebook.com/LSUHSC.